• 个人简介

  赖秀兰，永利3044集团官网应用数学研究中心副教授，博士生导师，永利3044集团官网吴玉章青年学者。主要从事生物数学与肿瘤免疫动力学领域的研究工作，聚焦于生物医学相关问题预测模型的数学建模、理论分析与生物计算。在生物医学预测模型的构建与分析、肿瘤免疫相互作用、癌症联合治疗的数学建模和计算等方面取得了一系列成果。当前研究重点包括癌症诊断与抗PD-1/PD-L1治疗相关的癌症演变动力学、空转数据分析、白血病复发机制，以及万古霉素用药方案优化。近年来，在PNAS、Science China Mathematics、SIAM Journal on Applied Mathematics、Journal of Mathematical Biology、Journal of Differential Equations、BMC Systems Biology、Bulletin of Mathematical Biology、DCDS-B等SCI核心期刊上发表论文30余篇，其中一篇论文荣获第十七届北京青年优秀科技论文。

  先后主持国家自然科学基金项目2项（青年基金项目1项、面上项目1项），主要参与1项国家自然科学基金重点项目。任中国数学会生物数学专委会委员、中国工业与应用数学学会数学生命科学专委会委员。受邀担任Nature Communications、Journal of Mathematical Biology、Scientific Reports、PLoS Computational Biology、SIAM Journal on Applied Mathematics等多个国际知名期刊的审稿人。

• 代表性文章

  [1]      Shizhao Ma, Xiulan Lai*, Exploring the role of osteoblast-lineage cells in the evolutionary dynamics of acute myeloid leukemia through a stochastic differential equation model, Mathematical Biosciences, 2026, January; 391: 109572.

  [2]      Xiulan Lai, Teng Yu, Modeling Combination Therapies and T Cell Exhaustion Dynamics in the Tumor Under Immune Checkpoint Blockade, Bulletin of Mathematical Biology, 2025; 87:128.

  [3]      Xiulan Lai#, Xiaopei Jiao#, Haojian Zhang, Jinzhi Lei*. Computational modeling reveals key factors driving treatment-free remission in chronic myeloid leukemia patients. NPJ Systems Biology and Applications, 2024. 10(1):45.

  [4]      Shizhao Ma, Jinzhi Lei, Xiulan Lai*. Modeling tumour heterogeneity of PD-L1 expression in tumour progression and adaptive therapy. Journal of Mathematical Biology, 2023, 86(3):38.

  [5]      Rujing Zhao, Xiulan Lai*, Evolutionary analysis of replicator dynamics about anti-cancer combination therapy. Mathematical Biosciences and Engineering, 2023, 20(1):656-682.

  [6]      Yu Chen, Xiulan Lai*. Modeling the effect of gut microbiome on therapeutic efficacy of immune checkpoint inhibitors against cancer. Mathematical Biosciences, 2022, 350:108868.

  [7]      Xiulan Lai, Avner Friedman. Mathematical modeling of cancer treatment with radiation and PD-L1 inhibitor. Science China Mathematics, 2020, 63: 465–484.

  [8]      Xiulan Lai, Xingfu Zou. Minimal wave speed and spread speed in a system modelling the geographic spread of black-legged tick Ixodes scapularis. Journal of Differential Equations, 2020, 269(9): 6400-6421.

  [9]      Jian Fang, Xiulan Lai*, Feng-Bin Wang. Spatial dynamics of a dengue transmission model in time-space periodic environment. Journal of Differential Equations, 2020, 269: 149-175.

  [10]    Avner Friedman*, Xiulan Lai. Free boundary problems associated with cancer treatment by combination therapy. Discrete and Continuous Dynamical Systems – A, 2019, 39(12): 6825-6842.

  [11]    Xiulan Lai, Avner Friedman. How to schedule VEGF and PD-1 inhibitors in combination cancer therapy? BMC System Biology, 2019, 13(1):30. 

  [12]    Xiulan Lai, Andrew Stiff, Megan Duggan, Robert Wesolowski, William E Carson 3rd, Avner Friedman*, Modeling combination therapy for breast cancer with BET and immune checkpoint inhibitors. The Proceedings of the National Academy of Sciences USA. 2018, 115(21):5534-5539.

  [13]    Xiulan Lai, Anthony Brown, Chuan Xue*, A stochastic model that explains axonal organelle pileups induced by a reduction of molecular motors. Journal of the Royal Society Interface. 2018, 15(148):20180430. 

  [14]    Xiulan Lai*, Avner Friedman. Combination therapy for melanoma with BRAF/MEK inhibitor and immune checkpoint inhibitor: a mathematical mode. BMC Systems Biology, 2017, 11:70.

  [15]    Xiulan Lai*, Avner Friedman. Exosomal microRNA concentrations in colorectal cancer: A mathematical model. Journal of Theoretical Biology, 2017, 415: 70-83.

 详细情况见： https://www.researchgate.net/profile/Lai-Xiulan

• 科研项目

  主持（负责人）：

  国家自然科学基金面上项目，2022.01-2025.12

  国家自然科学基金青年科学基金项目 ，2016.01-2018.12

  永利3044集团官网理工学科校内科研基金项目人才培育I类，2019.01-2021.12

  
  

  参与（骨干成员）：

   国家自然科学基金重点项目，2024.01-2028.12.

• 人才培养

指导硕士生12人，博士生4人。